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KMID : 0378019610040070095
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New Medical Journal
1961 Volume.4 No. 7 p.95 ~ p.106
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A Cytological Study of Human Peripheral Lymphocytes in a Case of Acute Lymphocytic Leukemia
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Abstract
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The author has recently encountered a case of acute lymphocytic leukemia and made a cytological study on the leukemic cells appearing in the peripheral blood in comparison with the normal lymphocytes from a child of the same age.
The author has reached the following conclusion after the study:
1. All the living lymphocytes are round formed, and it appears that the longer js the time between smearing and- fixation, the higher is the percentage of transitional forms; the older is the age of l)rnphocytes, the stronger is their ability of transformation.
2. The tongue-like protrusions of the cytoplasm and nucleus are characteristic of immature lymphocytes, and this is a useful point distinguishing acute lymphocytic leukemia from acute myelocytic leukemia.
3. Paralymphoblasts are the chief component of the peripheral blood in acute lymphocytic leukemia, and these cells have more tendency to become transitional forms as the time of fixation is delayed after the smear is made.
4 Lymphocytes contain two kinds of granules in their cytoplasm, namely azurophil=granules and azur-granules. The former appears to take part in cell respiration, and the latter in antibody production.
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KEYWORD
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